Abstract

DETERMINE THE GPS MUTATIONS IN ACROMEGALIC SAMPLE OF IRAQI PATIENTS

*Wathiq Abbas Aldraghi and Aseel Sami

Abstract

Acromegaly is a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH) after epiphyseal plate closure at puberty (Hodish and Barkan, 2008). Acromegaly most commonly affects adults in middle age, and can result in severe disfigurement, complicating conditions, and premature death if unchecked. Because of its pathogenesis and slow progression, the disease is hard to diagnose in the early stages and is frequently missed for years until changes in external features, especially of the face, become noticeable (Miller et al., 2011).

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