Abstract

FLOATING MATRIX TABLETS – A COMPLETE STUDY

S. Sethy*, V. V. Mishra and A. K. Rath

Abstract

Floating drug delivery system (FDDS) is a safe and efficient technology for drug delivery which has a bulk density lower than gastric fluids thus, remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. The drug is released slowly and almost completely at a desired rate from the system after which the residual system becomes liable to be emptied from the stomach. This results in an increase in the gastro retentive time, bioavailability and a better control of fluctuations in the plasma drug concentrations. It may of two types i.e., effervescent type & noneffervescent type. Effervescent systems include use of gas generating agents, to produce carbon dioxide (CO2) gas, thus reducing the density of system and making it float on the gastric fluid. The non effervescent floating drug delivery systems are based on mechanism of swelling of polymer in gastric fluid. Floating tablet is a promising approach with a view of obtaining faster action of the drug and would be advantageous in comparison to currently available conventional forms.

Keywords: Gastric emptying, Intragastric, Ingastric.