Abstract

NANOTECHNOLOGY BASED APPROACHES FOR TRANSDERMAL DRUG DELIVERY

Niranjan Bhat H., Afrasim Moin, D.V. Gowda*, Anuj Gupta, Ashish, Gritta Sebastian and Riyaz Ali M. Osmani

Abstract

The transdermal route of administration is recognized as one of the potential route for the local and systemic delivery of drugs. Transdermal drug delivery is a convenient method of drug administration enabling physicians to provide controlled delivery of drugs to patients with minimum discomfort. Compared to oral and parenteral routes, the transdermal route has the advantages of reducing gastrointestinal side effects and reducing drug degradation. However, the poor permeability of the stratum corneum often limits the topical administration of novel drug formulations. Though, there are various chemical and physical methods; to promote transdermal drug permeation by the disruption of the skin barrier. Although effective, tend to produce allergic reactions, skin irritation, and sensitization. Nanotechnology is a booming branch of science that also aids in the area of drug delivery and therapeutics. Several research findings proved that nanotechnology based drug delivery approaches are far more efficient for transdermal delivery than other conventional drug delivery systems. In present article, efforts have been taken with the intention to get thorough information of the mechanism of transdermal delivery along with a comprehensive review of diverse nanotechnology based approaches adopted for transdermal delivery till date.

Keywords: Drug delivery, Nanocarriers, Transdermal delivery, Nanoemulsion, Nanoemulgel.