Abstract

FORMULATION AND IN--VITRO EVALUATION OF BUCCAL MUCOADHESIVE TABLETS OF CATOPRIL BY USING NATURAL AND SYNTHETIC POLYMERS

Mubashshera S. Shaiikh*, Abhiijiit N. Merekar, Ganesh R. Godge and Mohiit R. Gaiikwad

Abstract

Captopril is widely used for the treatment of arterial hypertension, myocardial infarction and in diabetic nephropathy. The drawback of this drug is that, is taken three times daily, which may give poor patients compliance. In the present study, an attempt was made to decrease dosing frequency and increase bioavailability by preparing a buccal mucoadhesive tablets. Various polymers such as carbopol 934P, HPMC K4M, chitosan, and sodium alginate are used as a mucoadhesive polymers. Formulations are subjected to friability, drug content, surface pH, swelling index, moisture absorption, wash off test, mucoadhesive strength and dissolution study. All the results for all the formulations are within the official limit and acceptable. F5 Formulation containing combination of natural and synthetic polymers (carbopol 934p and chitosan) shows better mucoadhesive strength as well as drug release.

Keywords: Mucoadhesive Tablet, Buccal Mucoadesive Tablet, Captopril.