Abstract

ELECTROANALYTICAL DETERMINATION OF AZAPROPAZONE AT GLASSY ELECTRODE USING DIFFERENTIAL PULSE AND ANODIC SQUARE-WAVE VOLTAMMETRY IN PURE FORMULATION, PHARMACEUTICAL

Anwar A. Wassel* and H. A. M. Hendawy

Abstract

A sensitive electroanalytical method for determination of azapropazone has been investigated on the basis of the enhanced electrochemical response at glassy carbon electrode during oxidation of azapropazone, Cyclic voltammetric undergo one irreversible anodic peak at Ep= 0.48 mV in Britton - Robinson (BR) (pH 4.0). Cyclic voltammetric study indicated that the oxidation process is irreversible and adsorption controlled. The number of exchanged electrons in the electro -oxidation process was obtained. Differential pulse voltammetry (DPV) and square wave voltammetry (SWV) were studied and a linear calibration obtained from: 0.0014– 0.026 μg/ml, 0.014 – 0.134 μg/ml using DPV and SWV respectively. The RSD for five measurements were found in the ranges: 0.854% and 0.911% for DPV and SWV, respectively. Precision and accuracy of the developed method was checked by recovery studies. The method was applied to determine azapropazone in pure form, pharmaceutical formulations, and compared with official methods.

Keywords: Azapropazone; Voltammetry; Differential pulse; cyclic voltammetry; square wave voltammetry, Electrochemical, GCE, Pharmaceuticals analysis.