Abstract

THE EFFECTS OF MINI-DOSE ASPIRIN ON HEPATIC FUNCTIONS.

Dr. Omar Rashid Sadeq* MD., Ph.D

Abstract

Aspirin is the prototype of NSAIDs, that’s widely used as an anti aggregant for prophylaxis of ischemic heart disease (IHD), usually is given as 75 mg/d, aspirin is a non selective COX inhibitor, as well as is the only irreversible inhibitor of COX enzymes. Aspirin is metabolized into acetic acid and salicylates, hence aspirin can cause salicylism, in which signs and symptoms may range from mild nausea, vomiting, abdominal pain, lethargy, tinnitus and dizziness to severe such as seizures or cerebral edema depending on the dose consumed. Although very-low-dose (mini-dose) aspirin is used increasingly as a platelet aggregation inhibitor, no studies have been published on whether aspirin's hepatic effects occur at dosages of

Keywords: Aspirin, Antiaggregant, Ischemic heart disease. Salicylism, Cerebral edema.