Abstract

ANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS

Ebralidze L., Mskhiladze L.*, Ledoux A., Frédérich M., Bellahcène A., Bero J., Quetin-Leclercq J. and Bakuridze A.

Abstract

The present study evaluates the anticancer, antiplasmodial and antitrypanosomal potential of leaf extract of the buds and bark of Platanus orientalis. The buds and bark of the plant were extracted with dichloromethane. Concerning the cytotoxic activity, the two extracts of the plant have shown a good growth inhibition of cervical adenocarcinoma cell lines (HeLa cells), with an IC-50 of 10.1 μg/mL and 30.9 μg/mL, respectively. The activity was slightly lower for breast adenocarcinoma cell lines (MCF-7), with an IC-50 of 38.6 μg/mL and 31.6 μg/mL, respectively. The IC50 values were superior to 100 μg/mL for MDAMB-231 cells. The extracts showed also antiplasmodial (12.7 μg/mL for bark extracts and 35.3 μg/mL for buds extracts) and antitrypnosomal activities (20.0 μg/mL for bark extracts and 21.8 μg/mL for buds extracts).

Keywords: Platanus orientalis, Platanaceae, buds, bark, anticancer, antiplasmodial, antitrypanosomal.