Abstract

DRUG INTERACTIONS BETWEEN AYURVEDIC AND ALLOPATHIC MEDICINES-A REVIEW

Dr. Dhanya R.* and Dr. Anil Kumar Shukla

Abstract

Drug interaction is any modification of response of one drug by simultaneous administration of another drug. The interactions may be either synergistic or antagonistic. Use of Ayurvedic drugs and allopathic medications concomitantly has led to potential chances for interactions between the drugs of two systems. This paper deals with the drug interactions of some commonly used Ayurvedic and Allopathic drugs. Guggulu is known to interact with hypolipidaemics, anticoagulants, antihypertensives and thyroid medications. Garlic interacts with anticoagulants, NSAIDs by anti platelet activity. Aswagandha may potentiate the effects of barbiturates. Concomitant use of castor oil reduces the efficacy of antiarrythmic drugs, diuretics, fat soluble vitamins and antihistamines. Yashtimadhu increases potassium loss and so prolonged use with thiazide and loop diuretics may be harmful. Other examples include the interactions of herbs like Tulsi with paracetamol, Methika, Meshasringi etc. with antidiabetic drugs, Jatamamsi with benzodiazepines, berberine in Daruharidra with hypolipidaemic drugs and Vasa with theophylline. Proper knowledge of drug interaction can be useful. For example Risorine, an anti-tuberculosis drug has been developed on the basis of synergistic interactions of piperine from Pippali with rifampicin. Important mechanisms involved in ayurvedic- allopathic drug interactions are alteration of absorption and induction or inhibition of cytochrome systems. The methods to avoid these interactions include taking a detailed drug history before prescribing, correct timing of medications, identifying risky patients and risky drugs and proper regulation in the sale of medications. To conclude what becomes important is creating a detailed database about clinically relevant interactions of Ayurvedic and Allopathic drugs.

Keywords: Drug interaction, Ayurvedic, Allopathic.