Abstract

EFFECT OF CURCUMA AROMATICA ON NICOTINE INDUCED ALTERATIONS ON ESTROUS CYCLE

N. Poonkodi* and V. Elango

Abstract

effects of nicotine tartarate on female albino rat’s reproductive system were studied. The rats were divided into 4 groups. Group I: control animals received normal saline, Group II: injected with nicotine 4mg/kg, Group III: injected with nicotine4mg/kg and Curcuma aromatica 100mg given orally. Group IV: given Curcuma aromatica 100 mg/kg orally. Estrous cycle was examined daily by vaginal smear and animals in estrus phase were selected. At the end of the experiment, ovaries were removed and after weighing were prepared for various studies. Results showed that the length of estrous cycle in group II animals was increased significantly. Results showed that nicotine exposure significantly reduced IGF-I and aromatase mRNA expression relative to group I. In group III rats these pathological changes were reversed and there is no change in group IV rats.

Keywords: Ovary; Uterus; Nicotine; Estrous cycle; Aromatase.