Abstract

FORMULATION & IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF MEBHYDROLIN NAPADISYLATE

Joushan Ara, MD. Rabiul Hossain* and Puja Bhowmik

Abstract

Gastro retentive drug delivery systems (GRDDS) are the systems which are retained in the stomach for a longer period of time and thereby, improve the bioavailability of drugs. The objective of this study was to formulate gastro retentive floating matrix tablet of Mebhydrolin Napadisylate using different ratios of HPMC K4M & HPMC K100LV. The sodium bi carbonate and citric acid was used in combination as gas generating agent. The tablets were prepared by wet granulation method and evaluated for the pre and post compression parameters such as angle of repose, tapped density, bulk density, Carr’s Index, Hausner’s ratio, hardness, friability, weight variation, thickness, swelling index, In vitro buoyancy studies and In vitro drug release studies. The tablets containing Mebhydrolin Napadisylate released 61.6 to 87.6% of drug at the end of 10 hrs by In vitro release study. Formulation F3 containing HPMC K4M and HPMC K100LV at a ratio of 1:1 found to be the best formulation in terms of drug release and In vitro buoyancy time. The drug release followed the Higuchi model controlled mechanism of tablet Mebhydrolin Napadisylate. FTIR spectrums obtained suggest that there was no significant chemical interaction between the polymers and drug.

Keywords: GRDDS, Mebhydrolin Napadisylate, HPMC K4M, HPMC K100LV, Sodium bi carbonate.