Abstract

QUANTIC ANALYSIS OF THE EFFECT OF NICOTINE ON NEUROTRANSMITTERS

Lillhian Arely Flores-González, José Miguel Gutiérrez-Ramírez, Lorian Constanza Sánchez-González, Horacio Reyes-Solis, Alex Toledo-Vázquez and Manuel González- Pérez*

Abstract

Nicotine (NIC) is known for its adverse effects on health. It affects directly to Central Nervous System (CNS). NIC modifies the concentration of neurotransmitter (NT) and their specific function. The main goal of this work is to determine by Semi-empirical Parametrical Method 3 (SE-PM3) quantic analysis, the interaction between NIC and the main NT and their possible effects on the human’s CNS. Hyperchem is a molecular modeling computational program. Researchers use Hyperchem to analyze the Electron Transfer Coefficient (ETC) of the compounds and to identify the possible interaction between compounds. We found that NIC directly affects to NT. The effects of NIC on NT depend on of the functions of the human body. As a result, we found that the NIC interacts with all NTs, both as an oxidizing or reducing agent. The work team concluded that NIC has a direct effect on the interaction with the most common NT highlighting adrenalin, dopamine, aspartic acid, glycine, Gamma-aminobutyric acid (GABA) and serotonin. The information we got as part of this study is congruent with data reported in the literature.

Keywords: Nicotine, Neurotransmitters, Quantic analysis, Hyperchem, SE-PM3.