Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CARVEDILOL

Dr. Ananda Kumar. Chettupalli*, Narender Boggula, Eslavath Ravindar Naik, Dr. B. Vasudha

Abstract

The aim of the present research work was to enhance the solubility of Carvedilol by solid dispersion method and to formulate a mouth dissolving tablet. Drugs are more frequently taken by oral administration. The solubility of Carvedilol enhanced with different ratios of PVP by the solvent evaporation method .In-vitro release profile of solid dispersion obtained in SGF without enzymes and Ph 6.8 phosphate buffer indicate that 100% drug release found within 20 min. These solid dispersion were directly compressed into tablets using Crospovidone, sodium starch glycol ate, croscarmellose sodium and polyacrylic potassium in different concentrations as a super disintegrants. The prepared tablets containing the solid dispersion of Carvedilol having sufficient strength of 2.5-4 kg/cm2. The disintegrated in the oral cavity with in 21 sec. contain Crospovidone (5%) as super disintegrant.

Keywords: Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet.