Abstract

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE LIPOSOMES OF REPAGLINIDE FOR ORAL CONTROLLED DELIVERY SYSTEM

Shravya Lakshmi S., Parthiban S.*, Senthil Kumar G. P., Tamizh Mani T.

Abstract

The aim of the present investigation was to design a mucoadhesive liposomal system of Repaglinide for the treatment of type - 2 diabetes mellitus that is capable of delivering entrapped drug over an extended period of time. Mucoadhesive liposomal formulations were prepared by using different ratio of lecithin and cholesterol by thin film hydration technique followed by coating of liposomes by 0.1 % w/v of chitosan and were evaluated for entrapment efficiency, particle size, zeta potential, surface morphology and in-vitro drug release. Particle size and zeta potential of the F2 and CF2 formulation was found to be 413.5 and 830.9nm -40.9 mV and -46.8 mV respectively. Coating of liposomes resulted increase in particle size and also increases the zeta potential. Highest entrapment efficiency was observed in F1 and CF1 90% and 95%. The percent drug release from F1-F3 and CF1-CF3 was observed as follows F1- 79.04%, F2- 76.77%, F3- 64.32% and CF1-66.65%, CF2- 62.12%, CF3- 56.54% which follows first order drug release and non-Fickian diffusion mechanism.

Keywords: Repaglinide, Diabetes mellitus, mucoadhesive liposome, thin film hydration method, stability studies, in-vitro release