Abstract

NOVEL FRONTIERS IN NASO-BRAIN DRUG DELIVERY;CHALLENGES AND OPPORTUNITIES: AN OUTLOOK

Sandeep Kaur, Manoj Kumar Katual*, Radhika Sharma, Gurdeep Kaur, S. L. Harikumar

Abstract

Delivery of drugs through nasal route has been potentially explored as an alternative route for administration of vaccines and bio molecules such as proteins, peptides and non peptide drugs, hence it has attracted the interest of scientific community. Nasal route is beneficial for the drugs which are unstable on oral administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. It is thought that olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This Nasal route is alternative to parentral therapy and also useful for long term therapy. Nasal mucosa is highly vascularised and most permeable giving rapid absorption and onset of action. Nasal route is non invasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives good absorption of small molecules, than that of large molecules can be increased by absorption promoters. In this article is an overview of intranasal drug delivery with its various aspects like factors affecting nasal absorption, strategies to improve bioavailability are discussed.

Keywords: Intranasal drug delivery, Bioavailability, Nano-technology, Permeation enhancers.