Abstract

“ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF STEM BARK OF MYRICA NAGI (T.)”

Mihir K. Patel*, Arpit Shah and Maulika M. Patel

Abstract

Aim of the study: M. nagi is traditionally used in the treatment of various inflammatory conditions like chronic bronchitis and asthma and in relief of dental pain; however there is a scarcity of scientific data to support the ethnobotanical claim. The aim of the present study was to evaluate the analgesic and anti-inflammatory activity of MNSBEE in laboratory animals. Materials and methods: Analgesic activity was carried out by acetic acid-induced abdominal writhing and hot plate test in mice at the dose level of 100,200 and 400 mg/kg. Anti-inflammatory activity was carried out by carrageenan (acute) and cotton pellet granuloma (chronic) tests and in combination with MNSBEE (400 mg/kg) and diclofenac (5 mg/kg) in rats. Results: The pharmacological screening revealed that MNSBEE significantly increased pain latency in acetic acid- induced writhing and hot plate in mice and significantly inhibited paw edema volume in carregeenan-induced paw edema and significantly inhibited granuloma weight in cotton pellet granuloma model at the doses of 200 and 400 mg/kg, p.o. The combination of MNSBEE and diclofenac has been studied and found to be most significant antiinflammatory effect without toxic effect. Conclusion: The observed results suggested the MNSBEE showed significant analgesic and anti-inflammatory activity in acute as well as chronic conditions which support its folk medicine use. Thus, the combination of herbal product (ethanolic extract of Myrica nagi) with modern medicine will produce the best antiinflammatory action and will be useful for long-term treatment of chronic conditions.

Keywords: Myrica nagi, Analgesic, Anti-inflammatory, Carrageenan, Hot Plate.