Abstract

SUB ACUTE ORAL TOXICITY STUDY OF SWARNA BHASMA IN WISTAR RATS

Sanjaya Kumar Y.R.*, Sudesh Gaidhani N., Thamizh Selvam N., Sushant Parekar S., Ranjini K.R. and Vasanthakumar K.G.

Abstract

Swarna bhasma is an elixir / rasayana used in Ayurveda as rejuvenator and for therapeutic purposes since ancient times. In the present study, Swarna bhasma was evaluated for safety in Wistar rats by sub acute toxicity study. The test drug was administered to three groups of rats at therapeutic dose, 5 times of therapeutic dose and 10 times of therapeutic dose levels. No mortality or signs of toxicity was observed in Wistar rats during the study. Hematology and biochemical values did not alter significantly between test and control group. Internal organs did not reveal structural changes suggestive of toxicity upon gross examination and histopathology investigation. Swarna bhasma was found to be safe up to 13.5 mg/kg body weight in Wistar rats.

Keywords: Swarna Bhasma, rats, Sub acute toxicity.