Abstract

ENHANCEMENT OF DISSOLUTION OF FUROSEMIDE BY SOLID DISPERSION USING HYDROPHILIC POLYMER AND MODIFIED NATURAL CARRIERS

Navid Zuhar Khan*, Shivakumar S. and Yogananda U. K.

Abstract

Furosemide (FRMD) is a loop diuretic, poorly water- soluble (BCSClass II) drug. It is used for the treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal disease, including the nephrotic syndrome. Besides this it is also used for the treatment of hypertension. In order to enhance the extent of absorption, it is necessary to improve its solubility. To increase its solubility and dissolution rate, various solubility enhancement methods like physical mixing, solvent evaporation, kneading and hot melt by using carriers such as Poloxamer 407 and Modified xanthan gum in different ratios were investigated. Drug-carrier interactions were investigated by FTIR spectroscopy and differential scanning calorimetry. The studies showed that solubility and dissolution rate of Furosemide were distinctively increased in the prepared drug carrier mixture compared to that of pure Furosemide. The studies showed that dissolution and solubility parameters progressively improved with increasing the polymer proportion in the drug carrier mixtures. Poloxamer 407 in 1:3 ratio with the drug showed an increase in solubility and dissolution compared to the other polymers.

Keywords: Furosemide; Modified xanthan gum; Poloxamer 407; Solid dispersion; Dissolution enhancement; Physical mixing; Kneading; Solvent evaporation; Hot melt.