Abstract

FORMULATION AND CHARACTERIZATION OF MOUTH DISINTEGRATING TABLET CONTAINING ANTIHYPERTENSIVE DRUG

Rahul Sarode*, Suvarna Bhavar, V. J. Chaure, Dr. Subhash Deshmane and Dr. R. N. Purohit

Abstract

In this study mouth dissolving tablet of ramipril was prepared by direct compression method and simultaneously, the drug and excipient compatibility study was conducted to determine and select the best blend of drug and excipient formulation. Mouth dissolving tablet was formulated using different diluents like mannitol (DC), microcrystalline cellulose, with different superdisintegrants like sodium starch glycolate, crosspovidone. The six formulation were design and evaluated for powder parameter like Angle of repose, Bulk density, Tap density, Hausner’s ratio, Car’s index, after a satisfactory result of these preformulation parameter the tablet were prepared and subjected for evaluation like disintegration time, thickness, diameter, weight variation, friability and finally subjected for dissolution study. Finally the result were analyse and it was found that formulation 6shows better disintegration than other 5 formulation.

Keywords: SSG:-sodium starch glycolate, MCC:-microcrystalline cellulose.