Abstract

PHYTO-CHEMICAL STUDIES OF METHANOL EXTRACTS OF TINOSPORA CORDIFOLIA STEM BY GC-MS

Anita Sinha*, H. P. Sharma, Binod Singh and Amit Patnaik

Abstract

Plants are the almost exclusive source of drugs for majority of the world population. The phyto components present in Tinospora cordifolia, locally known as Gilloy, Guduchi or Amrita, is used in the treatment of various ailments in the long-established medicinal system in the state of Jharkhand, India and is also an anti-oxidant and immuno-modulator. Present study was carried out to investigate the phyto-constituenst of the Tinospora cordifolia which contain terpenoids, steroids, glycosides, flavonoids and phlobatannins etc. are confirmed by preliminary phyto-chemical studies. GC-MS analysis of methanol extract of the plant showed the presence of 64 bioactive compounds. Some of them are of great interest as they are either anti- cancer or anti-oxidant or both, such as pentanoic acid, propyl ester or valproic acid, phytol or 2-hexadecen-1-ol and 9, 12-octadecadienoic acid (Z, Z), benzenepropanoic acid, 2, 5-dimethoxy-, hexadecanoic acid, methyl Ester, octadecanoic acid, n-hexadecanoic acid or palmitic acid. Among all these reported anti-cancer compounds, n-hexadecanoic acid or palmitic acid was present in highest proportion (area 23.12%) in the GC-MS chromatogram.

Keywords: Tinospora cordifolia, Phyto-constituent, GC-MS analysis, Anti-cancer, Bioactive compounds.