Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF N-(2,4-DINITRO-PHENYL)-N’-(2,3,5,6-TETRAPHENYLPIPERIDIN- 4-YLIDINE)-HYDRAZINE

R. Kathirvel, M. Sathyanarayanan, S. Mohamed Rabeek and M. Seeni Mubarak*

Abstract

Piperidin is an important class of heterocyclic compounds which play a vital role in the field of medicinal chemistry. Several 2,6-disubstituted derivatives of these compounds are found to posses biological activities such as herbicidal, fungicidal, anticancer, anaesthetic etc. The synthesis of substituted piperidin-4-one derivatives using 2,4- dinitrophenyl-hydrazine from1,3-diphenyl acetone, variously substituted aldehydes and ammonium formate (amine) in ethanol medium under reflux-free condition is described to get 2,3,5,6- tetraphenyl-piperidinin-4-one. Which after incorporated with 2,4- dinitrophenyl-hydrazine using reaction condition to get target compound N-(2,4-Dinitro-phenyl)-N’-(2,3,5,6-tetraphenyl-piperidin-4- ylidine)-hydrazine. The characterized by FT-IR, 1HNMR, 13CNMR and Biological studies.

Keywords: FT-IR, 1HNMR, 13CNMR and Biological studies.