Abstract

ANALYTICAL METHODS OF PERINDOPRIL, REVIEW

Samer Housheh* and Lama Jdeed

Abstract

Perindopril erbumine is an antihypertensive, which belongs to the category of angiotensin-converting enzyme inhibitors (ACE inhibitors) that inhibit the conversion of angiotensin I to angiotensin II. The aim of this review is to focus on a comprehensive update of analytical methods for determination of Perindopril and its metabolites in human plasma and in pharmaceutical preparations. It has been described using TLC, RP-HPLC, GC, Mass and UV methods. This review provides detailed information on separation conditions for perindopril alone, perindopril in presence of its degradation products or with its combinations.

Keywords: Perindopril, Chromatography, HPLC, GC, MS, HPTLC, UV.