Abstract

FORMULATION AND IN-VITRO EVALUATION OF EFFERVESCENT FLOATING DRUG DELIVERY SYSTEM OF CIPROFLOXACIN TABLET.

Vinit S. Khairnar*, S. T. Patil, S. A. Tadavi, V. H. Jain, S. P. Pawar

Abstract

The effervescent floating drug delivery systems that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. Effervescent Floating tablets of Ciprofloxacin were prepared by using two different synthetic polymers such as HPMC K 100 M, and HPMC E15. Each polymer was used in combination with two different effervescent agents like NaHCO3 and CaCo3. The floating tablet is prepared by direct compression method. The mixture of Sodium bicarbonate with citric acid and calcium carbonate with citric acid was used as a gas generating agent. Floating properties and in-vitro drug release properties were optimized by changing the effervescent agent and total six formulations were developed. Pre formulation studies shows that all the formulation had poor flow property. In this study it was confirmed that the effervescent floating tablet of ciprofloxacin may be increase the retention time and absorption.

Keywords: FDDS, effervescent agent, calcium carbonate, floating time.