Abstract

INCIDENCE AND PHARMACOLOGICAL MANAGEMENT OF HYPOTHYROIDISM IN PATIENT SUFFERING FROM DIABETES MELLITUS (Type-II)

*Bidhan Chand Mahato, Sabyata Gautam and Bimbishar Bhattrai

Abstract

Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Hypothyroidism is failure of the thyroid gland to produce sufficient thyroid hormone to meet the metabolic demands of the body. The coexistence of diabetes mellitus (DM) with hypothyroidism is a known clinical observation. This is a hospital based prospective cross-sectional study carried out in OPD of Alka Hospital Pvt. Ltd. A total of 208 patients with known or newly detected cases of Type-II DM aged of any group were selected randomly and subjected to evaluation for thyroid function-clinically and biochemically and other relevant investigations were done. Data evaluation was based upon SPSS 20.0 for descriptive and correlation analysis. Out of total 208 Type II DM patients, hypothyroidism (clinical and subclinical) in diabetes was observed to occur in 42(20.19%) patients. Majority of subjects were found to be females. The mean age group at diagnosis of Type-II DM was 60-69 years. Out of 69 patients, 56.52% of diabetes and thyroid status patients were found to be overweight. Metformin was the most commonly prescribed medication. Losartan was the drug of choice in the treatment of diabetic hypertension. Atorvastatin was the most common anti-hyperlipidemics drug prescribed to the patient. Thyroxin was the drug of choice in the treatment of diabetic hypothyroidism. Subclinical hypothyroidism was more common in female age group 60-69. Majority of patient were overweight.

Keywords: Diabetes Mellitus, Subclinical Hypothyroidism, Prescription Pattern, Incidence.