Abstract

STUDY AND DEVELOPMENT OF TARGETED DRUG DELIVERY SYSTEMS AND DOSAGE FORMS

*Bakuridze A. D., Vacnadze V.I., Joxadze M.S., Mosidze E. E., D.T. Berashvili, M. Metreveli and V. Mshvildadze

Abstract

Malignant cancer belongs to the number of the most widespread diseases in the world. With the purpose of increasing the efficiency of anti-cancerous medications significant attention is paid to their targeted delivery to the relevant organ, tissue and cell. High level of selectivity is reached when the active substance of the drug is transported by the liposomes. On the Black Sea coast of Adjara, Batumi, in botanical garden, grow up to 17 introduced species Magnolia. The bioactive components such as magnolol, honokiol, 4-O-metilhonakiol according to numerous pharmacological studies have shown cytotoxic, antistress, antidepressant, antioxidant, anti-inflammatory activity. It was found that leaves of the study objects contain liriodenins and lanuginosin, in the crust off branches was established content of liriodeninis and d-kaaverin, bark contains liriodenin, kaaverin and magnophlorine. By mean of technological and pharmacologic researches, innovative liposomal solution has been developed, which is characterized by selective cytotoxic activity and is safe for healthy – normal cells. It is offered total alkaloids obtained from Magnolia oficinalis leaves and Magnolia glauca cortex, as liposomal medication- lyophilized powder, with the average diameter of liposomes 120nm, with 62% involvement of active substance.

Keywords: Targeted drug delivery, Cytotoxic, Development of dosage form.