Abstract

FORMULATION OF ANTIBACTERIAL FAST DISSOLING ORAL FILMS BASED ON ISPANI SPHAGNUM PEAT WATER

A. Tsertsvadze*, L. Ebralidze, D. Berashvili, I. Matchutadze and A. Bakuridze

Abstract

Due to the high frequency of acute respiratory desseases and particularly increased number of antibiotic-resistant strains development of antibacterial composition based on natural antibacterial component is one of the major interest for researchers. Besides fast dissolving film is an alternative form of tablet and capsule, which ensures drug systemic absroption through mucous membrane of mouth to treat respiratory desseases (pharungitis, tonsillitis, flu etc). Importance of research concernes the difficulties of swallow or chew of oral solid dosage forms by pediatric and geriatric patients. Ispani sphagnum peat water of natural origin is used as natural antibacterial component, it expresses antibacterial effect on 4 test culture: Acinetobacter spp., E. coli, S. aureus, K. Pneumonia respect. At the same time Ispani is distinguished by high content of essential elements. In the article formulation of ibuprofen and paracetamol containing fast dissoving oral film is determined. Films are prepared by solvent custing method. Optimal composition was determined based on physical and technological properties of films. Also quantitive amount of API and dose uniformity is evaluated.

Keywords: Peat peloid water; Fast dissolving oral films; Disintegration time; Natural antibacterial.