Abstract

THE EFFECT OF METHIDATHION ON SEX HORMONES, SPERM PARAMETERS AND TESTICULAR TISSUE IN MICE

Sami J. Al-Maliki and Eman H. Rahi*

Abstract

The present study aimed to identify the effect of methidathion on sex hormones, sperm parameters and testicular tissue in mice Mus musculus. Adult male mice divided into three groups (8 for each group), the first group i.p injected with normal saline as a control group, the second and third groups were i.p injected with (1.2, 2.4mg/kg of body weight) methidathion respectively for 15 day. The level of LH wasreduced in mice given high dose methidathion and decrease levels of testosterone in low and high doses compared with control group.A significant decreased in number of sperm after methidathion injection and significant increased in proportion of malformation sperm rate shown in high dose compared with control group. histopathological examination of testes showed analysis in some seminiferous tubules.

Keywords: methidathion, histopathology, sperm, hormones.