Abstract

ANTIDIABETIC AND HYPOLIPIDAMIC EFFECTS OF COSTUS SPICATUS JACQ. RHIZOME EXTRACT AGAINST STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS

S. Azhagumadhavan, Arjun Pandian, P. Vinayaga Moorthi and Ganesan Sivamani*

Abstract

The present study of antidiabetic effects of rhizome extracts of C. spicatus on STZ in diabetic rats was evaluated, important mechanism; underlying hyperglycemia in diabetes mellitus. Excess of glucose in blood leads diabetes. It reacts with haemoglobin and forms glycosylated. Therefore, the total haemoglobin level is decreased in STZ diabetic rats. Administration of C. spicatus ethanolic rhizome extract reversed the total haemoglobin levels in STZ diabetic rats. Our study we observed that haemoglobin level is lowered in diabetic treated rats. After twenty eight days treatment ethanolic rhizomes extract showed important reduction of blood glucose level. It showed effectively maintain blood glucose level in normal and STZ induced diabetic rats. Different group of animals were used; ethanolic extract of C. spicatus treated groups (200 and 300 mg/kg BW) another treated groups glibenclamide, used as standard, results in rats showed a significantly increased insulin level when compared with diabetagenic rats treated groups as well as in the group of glibenclamide.

Keywords: Blood glucose, Diabetic, Ethanolic extract, Glibenclamide, Insulin level.