Abstract

PROTECTIVE EFFECTS OF VITAMIN E ON NITAZOXANIDE ADVERSE EFFECTS

Gamal El-Din Shams, Abd El-Alim Fouad and Noha Naiem*

Abstract

This study to evaluate the protective effect of Vitamin E (18mg/kg, P.O. once daily) on Nitazoxanide adverse effects (18mg/kg, P.O. once daily) and its effect on liver, kidney, blood and antioxidant enzymes for three weeks. Then tissue and blood samples were collected on 1st, 7th, 14th and 21th days post-treatment to assess the protective effect of Vitamin E. Our results indicated that Vitamin E has hepato-nephro-protective and there was a decrease in the elevation of liver enzymes caused by Nitazoxanide like ALT, AST and ALP and kidney parameters like creatinine and urea, and there was a normalize in all blood parameters which decrease by Nitazoxanide and finally there was a significant increase in antioxidant enzymes like CAT, SOD, GPX and a significant decrease in MDA, beside showing decrease in fatty change of liver caused by Nitazoxanide administration, as demonstrated by hepatic histopathology. Also, showing decrease in aggregation of chronic inflammatory cell caused by Nitazoxanide administration, as demonstrated by kidney histopathology. Therefore, Vitamin E should be taken with Nitazoxanide to decrease its side effects.

Keywords: Nitazoxanide, Parasitic diseases, Vitamin E.