Abstract

EVALUATION OF ANTIHISTAMINIC AND BRONCHODILATOR ACTIVITY OF A SIDDHA DRUG NAAURUVI KUZHI THYLAM

*Esaivani S.

Abstract

The prevalence of allergy and asthma (Suvasa irumal ICD-DBA1.3)has risen in the recent years despite an improvement in the generalhealth of the population. Bronchial asthma (Suvasa irumal) is one ofthe most complex disorders of the airway characterized by reversibleairway obstruction inflammation, bronchial hyper-responsiveness andexcessive mucous production. Naauruvi Kuzhi thylam (NKT) is aSiddha herbal formulation indicated in literature for the managementof Asthma (Suvasa irumal). However the drug is not ethicallyvalidated hence the present study was focused to evaluate the in vitroantihistaminic action of NKT in isolated guinea pig ileum and in vivobronchodilator activity was carried out in four groups of guinea pigeach consisting of five animals. Group 1 was treated as control, GroupII received NKT at the dose 250 mg/kg and Group III animals received NKT 500 respectively.Group IV animals received the standard drug Chlorpheniramine maleate 2mg/kg. Prior todrug treatment each guinea pig was exposed to an atomized fine mist of 2% w/v histaminedihydrochloride aerosol. The results were statistically analysed by one way analysis ofvariance (ANOVA) followed by Dunnet “t” test. The results conclude that the study drugNKT possess antihistaminic and bronchodilator activity.

Keywords: Naauruvi Kuzhi thylam (NKT), Traditional medicine, Herbal medicine, Antihistaminic action, Anti-asthmatic, Bronchodilator, Bronchial asthma.