Abstract

ANTIBACTERIAL ACTIVITY OF ZINC SULPHATE AND SILVER NITRATE AGAINST HUMAN PATHOGENIC BACTERIA

Dinesh Kumar*, Archana Gajbhiye, Vipin Nagda and Asha Arora

Abstract

Metals enroutes various metabolic pathways forming the enzymatic suffixes, permeability indices or chelates of plasma. Through these entities either they promote or decline the metabolic activity depending upon the metal and targeted organism. In the present study the antimicrobial activity of zinc sulphate and silver nitrate was evaluated against human pathogenic Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli. The antimicrobial assay was performed by agar well diffusion method. The minimum inhibitory concentration (MIC) of zinc sulphate was observed to be the lowest for Escherichia coli i.e. 1.2±0.035mg/ml and of silver nitrate was lowest against Staphylococcus aureus i.e.0.05±0.035. Both metal salts exhibited good antimicrobial performances. The bactericidal effect and a broad activity spectrum of these compounds reveal their scope as suitable candidates for the higher step of drugs fabrication.

Keywords: Zinc Sulphate, Silver Nitrate, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, MIC.