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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

ALTERNATIVE, COST EFFECTIVE SYNTHESIS OF (3-(2- (DIMETHYLAMINO) ETHYL)-1H-INDOL-5-YL) METHANOL FROM 5-BROMO-1H-INDOLE

S. Venkat Rao*, Rajeev Kumar Dubey, K. Hariprasad, P. Reddaiah and Ramesh Babu Potluri

Abstract

Synthesis, characterization of a key starting material (3-(2- (dimethylamino) ethyl)-1H-indol-5-yl) methanol from commercially available raw material 5-Bromo-1H-indole; the main improvement in this synthesis is the simultaneous reduction of three carbonyl groups at time with an inexpensive reagent vitride.

Keywords: Synthesis, Indole derivative, vitride, selective reduction of three carbonyl groups with less pyrophoric reducing agent

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