Abstract

P62 CROSSTALK IN CANCER THROUGH SELECTIVE AUTOPHAGY

Md. Ariful Islam and Pinghu Zhang*

Abstract

p62/SQSTM1 is a stress-inducible protein and contain to regulate oneof- a-kind signal transduction pathways such as cell survival and cell death. LC3 binding proteins resulted in the popularity of autophagy and p62. Moreover, the essential position of p62 in directing ubiquitinated cargos in the direction of autophagy in addition to compaction of these cargos. This multifunctional position of p62 is explained through its capability to engage with numerous key components of various signaling mechanisms. Now not incredibly, p62 is needed for tumor transformation as a result of its roles as a key molecule in nutrient sensing, as a regulator and substrate of autophagy. In this review, we discuss the p62 crosstalk on cancer through selective autophagy.

Keywords: p62, autophagy, ubiquitin.