Abstract

RECENT ADVANCE IN ANTI-CANCER ACTIVITY OF INDOLE DERIVATIVES

C. Buvana*, R. Suresh, Y. Haribabu and P. K. Manna

Abstract

Indole is a bicyclic aromatic heterocyclic organic compound comprising of a six membered benzene ring fusedto a five-membered nitrogen-containing pyrrole ring. It is an excellent scaffold in drug discovery which provides numerous opportunities in the discovery of novel drugs with different mechanism of action. It has a very unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. A vast research has occurred on indole and its derivatives which resulted in many approved indole containing drugs in the world market as well as many are in the pipeline stages. The recent identification of an indole analog as a potential new anticancer lead. Indole nucleus is continuously drawing interest for development of newer drug moiety due to its wide range of activities like anticancer, antibacterial, antifungal, anti-malarial, anticonvulsant and anti-inflammatory. The research is going on in nucleus. In recent years, a wide range of research has been done in the field of anti-cancer drug development. Since indole nucleus has shown quite good response as an anticancer agent, hence this nucleus has become an interest in the field of research. Indole is present in Vinca alkaloid which can be used as an anti-cancer agent. So keeping in mind this point indole has been used for better anti-cancer activity of target compound. This review was focused on the indole and its derivatives that are now in development.

Keywords: Indole, Anticancer, Anti bacterial, Anti-inflammatory.