Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW

Akshay H. Bhoye*, AbdulKhalique A. Shaikh, Dr. Dhiren P. Shah and Tejas J. Patel

Abstract

Transdermal drug delivery system are topically administered medicaments. Transdermal patches are pharmaceutical preparation of varying sizes, containing, one or more active ingredient, intended to be applied to the unbroken skin in order to deliver the active ingredient to the systemic circulation after passing through the skin barriers, and it avoid first pass effect. Transdermal patches delivers the drugs for systemic effects at a predetermined and controlled rate. Through a diffusion process, the drug enters the bloodstream directly through the skin. Delivery of drugs through the skin for systemic effect, called transdermal delivery was first used in 1981, when Ciba-Geigy marketed Transderm V (present day marketed as Transderm Scop) to prevent the nausea and vomiting associated with motion sickness. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variation.

Keywords: Transdermal Delivery, Patches, Diffusion.