Abstract

A RECENT REVIEW ON INTRANASAL MICROEMULSION: A NOVEL DRUG CARRIER SYSTEM

Halde B. R.*, Darekar A. B. and Saudagar R. B.

Abstract

Nasal drug delivery has been used as an another route for the systemic availability of drugs restricted to intravenous administration. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in fast systemic drug absorption. The advantages, disadvantages, various aspects of nasal anatomy and physiology, mechanism of drug transport from nose brain, drug selection criteria to cross BBB/Blood-CSF barrier are discussed briefly. In addition, intranasal drug delivery enables dose reduction, rapid attainment of therapeutic blood levels, quicker onset of pharmacological activity, and fewer side effects. Microemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water and surfactant, frequently in combination with a cosurfactant with a droplet size usually in the range of 10-100 nm. The main purpose of this study is the use of microemulsion technology in drug targeting to the brain along with mechanism of the nose to brain transport, formulation and formation of the microemulsion and its characterization.

Keywords: Nasal drug delivery, Microemulsion, Nose to brain transport, Drug carrier, Target site.