Abstract

A REVIEW ON SOLID DISPERSIONS

*Dr. A. Seetha Devi, K. Vasundhara and S. Meraj Sultana

Abstract

Enhancement of solubility, dissolution rate and bioavailability of the drugs in drug development of hydrophobic drugs is a great challenge. Over the years a variety of solubilization techniques have been studied and widely used, as more than 40% of the newly developed drugs are poorly water soluble in pharmaceutical field. To improve such solubility issues, solid dispersion technique is widely used. The solubility behaviour of the drugs remains one of the most challenging aspects in formulation development. Solid dispersions are generally prepared with a drug which is having poor aqueous solubility and with a water soluble hydrophilic carrier. Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability. So, solid dispersion technique is an efficient tool for increasing the oral bioavailability and dissolution rate of a range of hydrophobic drugs. This article reviews preparation of solid dispersion like selection of carrier, classification, characterization, their advantages, limitations and applications.

Keywords: Solubility, solubilization techniques, Solid dispersions.