Abstract

IN VIVO STUDIES & SEM OF CONTROLLED POROSITY OSMOTIC PUMP (CPOP) TABLET OF ATENOLOL

Ayesha Sultana* and D. Varun

Abstract

The objective of the present research was to explain in detail about in – vivo studies, to determine the pharmacokinetic parameters which were estimated by comparing the marketed Atenolol tablets (Texanolol- AM) with the optimized CPOP tablet of Atenolol in rabbits and by analysing in UV Spectrophotometer. The Cmax, tmax, AUC, AUMC and MRT were estimated. The animal testing is considered to be a major element of in – vivo research. This study helps in observing the overall effects of an experiment. The bioavailability study is performed to characterize the plasma concentration versus time profile. CPOP works on the principle of osmosis releasing drug at zero order kinetics so better control over drugs. In vivo performance is possible releasing the drug after an initial lag. The core tablet consists drug and osmogen in optimum quantity with other excipients. The surface morphology of coating membrane of the optimized formulation was examined by using Scanning Electron Microscopy (SEM) before and after dissolution, it was observed microporous pores are formed after dissolution.

Keywords: Atenolol, Bioavailability, In vivo, Pharmacokinetic, SEM, Texanolol-AM,