Abstract

IN VITRO ANTICANCER ACTIVITY OF ETHANOLIC LEAF EXTRACT OF Acampe praemorsa (Roxb.)

G. Soumiya*, Dr. B. Christudhas Williams and Dr. R. Mary Suja

Abstract

Orchidaceae is one of the largest families among angiosperms. Recently there has been tremendous progress in medicinal plant research however orchids have not been exploited fully for their medicinal application. The main objective of the present investigation is to evaluate the in vitro cytotoxic activity of the crude ethanolic leaf extracts of Acampe praemorsa (Roxb.) A549 (lung carcinoma) cell lines using MTT assay. The IC50 value was determined as 14.63μg/ml. The concentration of ethanolic leaf extracts of Acampe praemorsa (Roxb.) of 6.25μg/ml inhibit the growth of 85.9%, 1.25 μg/ml inhibit the growth of 73.9%, 25μg/ml inhibit the growth of 57.9%, 50μg/ml inhibit the growth of 49.0% and 100μg/ml inhibit the growth of 34.3% The obtained results showed antitumor and cytotoxic effect of the extract against A549 (lung carcinoma) cell line support the ethnomedical use of Acampe praemorsa (Roxb.).

Keywords: Acampe praemorsa, cytotoxic, epiphyte, lung carcinoma, MTT Assay.