Abstract

STUDY OF THYROID FUNCTIONS IN TYPE 2 DIABETES MELLITUS AND RELATIONSHIP WITH OBESITY IN A TERTIARY CARE HOSPITAL, BANKURA, WEST BENGAL

Dr. Sumanta Banerjee*, Dr. Santa Saha (Roy), Dr. Pinaki Sarkar, Dr. Biswanath Sharma Sarkar and Dr. Dibakar Haldar

Abstract

Type 2 diabetes mellitus (T2 DM) is a well-recognized cause of premature death, disability and multi-organ disturbances and the rising trend of it invite more metabolic problems worldwide. Central obesity along with sedentary life style is one of the components of syndrome- X and a major risk factor of T2 DM. The objective of the study was to find out the inter-relationships among thyroid function (Serum TSH, T4, T3 levels); glycemic status (HbA1c and fasting plasma glucose, FPG) and obesity in patients of T2 DM. A descriptive and crosssectional study was conducted over a Period of 12 months among 87 patients suffering from T2 DM (uncontrolled) without known thyroid or kidney disease, and attending the Diabetes and Endocrinology Special Clinic of BSMCH, Bankura. The selected patients were interviewed and clinically examined to get the vital and physical statistics. Blood samples were collected and biochemical analyses were done following standard protocols. Data obtained were codified and analysed using appropriate statistical methods and software package. This study shows that duration of diabetes was significantly related to TSH and BMI. HbA1c had significant positive relationship with TSH, BMI and negative relationship with T4, T3. FPG had significant negative relation with T4. BMI was significantly related to TSH, T4, T3. Metabolic disturbances in diabetes can be manifested as hypothyroidism and obesity and these problems are increased with the chronicity and uncontrolled glycemic conditions.

Keywords: Diabetes mellitus; Subclinical hypothyroidism; HbA1c; BMI.