Abstract

GREEN UV SPECTROPHOTOMETRIC METHOD FOR ASSAY OF PROPRANALOL HYDROCHLORIDE TABLETS

*Vineeta Khanvilkar, Ummehani Tinwala, Meenal Suryavanshi and Shubham Auti

Abstract

Spectrophotometric analysis of majority of water insoluble drugs includes use of organic solvents like methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formaldehyde, toluene, acetone, hexane for extraction purpose. The primary disadvantage of organic solvents is their high cost and disposal issue along with the toxicity associated with them. Their long term exposure causes serious effects such as neurological disorders, chronic renal failure and liver damage. Therefore there is need for the development of alternative nature friendly methods for solubilization of such drugs. Techniques namely hydrotropy and mixed-solvency are available in the literature for solubilization of such drugs. The present investigation is an attempt to show application of hydrotropic technique using aqueous solutions of Sodium acetate and Sodium citrate for extraction of poorly water soluble drug, Propranolol hydrochloride from its tablet formulation. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method.

Keywords: Sodium acetate, Sodium citrate, Propranolol hydrochloride (PHL), Specific absorbance method.