Abstract

FORMULATION AND EVALUATION OF NANOPARTICLES OF EPROSARTAN MESYLATE

Nihar Ranjan Kar* and Manisa Patel

Abstract

The work presented herewith has the aim to prepare and evaluate the nanoparticles of Eprosartan Mesylate ,an antihypertensive drug which is poor aqueous soluble and also having very less bioavailabily(13%) and higher dose(400-600mg).The reason behind to formulate it as nanoparticle is to increase its entrapment efficiency so that the dissolution of the drug will be improved. For this purpose Methapolyacrylate polymers(Eudragit L-100 or Eudragit S-100) are taken for slow release the drug with a suitable solvent(PEG-200) and stabilizers to increase compatibility of drug with polymers.The prepared Nanoparticles are evaluated from estimation of particle size to particle size distribution, drug-polymer interaction study by FTIR, compatibility study by DSC with short term stability analysis.

Keywords: Nanoparticles,Eprosartan Mesylate,Eudragits, Particle Size Determination, Zeta Potential, FT-IR Study, DSC Study, Stability Analysis.