Abstract

MONONUCLEAR LINEAR-SHAPED ASSEMBLIES OF N,N’- DIETHYLBENZIMIDAZOLYDINE BASED IONIC LIQUID COORDINATED TO AG(I)- AND CU(I)-NHC AND THEIR ANTIBACTERIAL AND ANTIOXIDANT APPLICATIONS

A. G. Bharathi Dileepan, R. Mathumidha, D. Maruthamuthu, R. Ranjith, S. Priscilla Prabavathi and Shameela Rajam*

Abstract

A benzimidazolydine based ionic liquids containing ethyl substituents (L1) were prepared and further converted to ionic silver and copper complex were evaluated for antibacterial and antioxidant properties as evidenced by elemental analysis, FT-IR, (1D and 2D) NMR and EIMS data followed by investigating the antibacterial and antioxidant activity. The L1, Ag-NHC and Cu-NHC existed and screened for antibacterial activity based on the zone of inhibition, Minimum Inhibitory Concentration determination and stability studies against Staphylococcus aureus and Staphylococcus epidermidis. The standard drug used was ascorbic acid. Ag-NHC showed maximum inhibitory effects on the radicals [IC50 = 45.3 μM (DPPH), 47.1 μM (OH), 49.2μM (NO)].

Keywords: NHC, metal complexes, spectral characterization, antibacterial, antioxidant.