Abstract

EVALUATION OF ANXIOLYTIC ACTIVITY OF SUBSTITUTED 1, 2, 4-TRIAZOLE BEARING IMINO, FIVE MEMBERED HETEROCYCLIC MOIETY

D. Kumudha*, T. Kalavathi and B. A. Viswanath

Abstract

A series of 4-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-5-substituted phenyl-4H-1,2,4-triazole-3-thiol (8a-d), 5[(3-mercapto-5-substituted phenyl-4H-1,2,4-triazol-4-yl)methyl] 1,3,4–oxadiazole-2-thiol (9a-d), 4-{(5-mercapto-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl]methyl} -5-substituted phenyl-4H-1,2,4-triazole-3-thiols (10a1-a2-10d1-d2), 2- (3-mercapto-5-substituted phenyl)-4H-1,2,4-triazol-4-yl)-N1-[(1E)- substituted phenyl methylene) acetohydrazides (Schiff’s bases) (11a1- a6-11d1-d6), 2-(3-mercapto-5-substituted phenyl-4H-1,2,4-triazol-4- yl)-N-(4-oxo-2-substitutedphenyl 1,3-thiazolidin-3-yl) acetamides (12a1-a3-12d1-12d3) were synthesized. All these synthesized compounds are characterized by IR, 1H-NMR, 13C-NMR, Mass spectral analysis. In the present work, the test compounds 8a-d, 9a-c, 10a1, 10b1, 10c2, 11a1, 11b2, 11c3, 12a1, 12b2, 12c3 are evaluated for Anxiolytic activity by Hole board test, Staircase test. All the test compounds are showed non-significant anxiolytic effect expect 8d, 11a1, 11b2, 11c3 which showed moderate activity when compared to standard.

Keywords: 1,3,4-thiadiazole, 1,3,4-oxadiazole, 1,2,4-triazole, 4-thiazolidinone, Schiff’s bases, Anxiolytic.