Abstract

GREENER APPROACH OF SYNTHESIS OF AZO DERIVATIVES AND BIS- PYRAZOLE DERIVATIVES ALONG WITH ANTIMICROBIAL SCREENING

Prashant P. Chaudhari* and Shankarsing S. Rajput

Abstract

A clean, efficient and solvent free method for the synthesis of Azo compounds was carried out with the help of PbO nanoparticles. They have been synthesized by the reaction between 1-(N-methylpyridin-2- yl)pyrrolidine/ piperidine -2,5/6-dione and propionaldehyde at room temperature with the help of green chemistry. PbO nanoparticles employed as an efficient catalytic tool due to efficient, renewable and eco-friendly heterogeneous characteristics. The bis pyrazoles are synthesized by a simple eco-friendly microwave instigated solvent free synthesis. It was carried out by the reaction of corresponding bischalcones : 3,4/5-bis((E)-2-chlorobenzylidene)-1-(N-methylpyridin-2- yl)pyrrolidine/ piperidine -2,5/6-dione with hydrazine hydrate in presence of neutral Alumina. This method furnished various advantages, such as straight forward work-up procedure, environmentally benevolent, neutral condition and high yield. All the derivatives were characterized and interpreted for antimicrobial activities.

Keywords: Green Chemistry, clean, Solvent free, pyrrolidine-2,5-dione, piperidine-2,6- dione, propionaldehyde, hydrazine hydrate.