Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG BY USING VARIOUS SOLUBILITY ENHANCEMENT TECHNIQUES

Priyanka Hanumant Pawar*, Dr. Nilesh Khutle and Harshada Dalvi

Abstract

A success of formulation depends on how efficiently it makes the drug available at the site of action. Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. The bioavailability issue can be due to insufficient solubility or permeability. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for drugs. This is true for parenterally, topically and orally administered solutions. Hence various techniques are used for the improvement of the solubility of poorly water soluble drugs. This article explains the process of solubilization, Need for solubility enhancement, Factor affecting the solubilization and Methods of solubility enhancement.

Keywords: Solubility enhancement techniques, Solubility, Permeability, Poorly water soluble drugs.