Abstract

ESTABLISHMENT OF RICE HUSK BY-PRODUCT AS PHARMACEUTICAL EXCIPIENTS

Anil Kumar*, Durga Prasad Patel*, Gajendra Kumar Patel, Deepika Singh, Anand
Kumar Prasad and Dr. Khomendra Sarva

Abstract

Rice husk is a value added material for pharmaceuticals because ricehusk produce significant role as producing cellulose, which used as anexcipients in pharmaceuticals. Rice husk has such compatibleproperties, which can enhance the disintegration process with optimumrequired at reach to that of standard level of pharmaceuticaldisintegrating agents. Rice husk extracted celluloses are previouslyused as disintegrating agents in pharmaceuticals. To utilized rice huskas disintegrating agents to promote its activities in differentparameters. Because 1000gm of rice husk considered only 20% weightof cellulose, on that of 50% is pure cellulose and rest of 25 to 30% is lignin and 15 to 20% issilica as well. So that would be costly to perform extraction process to separate out thesecomponents from rice husk, as per guidance of teachers , constriction of modules to enhancethese activities to perform disintegration evaluation with directly using rice husk tablet indisintegration medium, and other evaluation parameters to be done thoroughly. Most of thehusk from the milling is either burnt or dumped as waste in open fields and a small amount isused as fuel for boilers, electricity generation, bulking agents for composting of animalmanure, etc The exterior of rice husk are composed of dentate rectangular elements, whichthemselves are composed mostly of silica coated with a thick cuticle and surface hairs. Themid region and inner epidermis contain little silica confirmed that the presence of amorphoussilica is concentrated at the surfaces of the rice husk and not within the husk itself. Thechemical composition of rice husk is similar to that of many common organic fibres and itcontains of cellulose 40-50 percent, lignin 25-30 percent, ash 15-20 percent and moisture 8- 15 percent. The typical properties of rice husk are indicated in Table 03. The particle size and the specific surface area can provide desirable flow characteristics, which are exploited to improve the properties of dry powder in various processes, such as tablet. It is also used to stabilize emulsions and as a thyrotrophic agent, thickening and suspending gels and for semisolid preparation. In aerosols is used to promote the suspension of particles and minimize the clogging of spray nozzles. In addition, it can be used as a disintegrating agent in tablets and as a dispersant for powders or suppositories. It is known that the rice husk is an important silicon dioxide source. Silicon dioxide (SiO2) is a composite of a remarkable structural complexity, presenting 12 different crystal forms. As well as different brands of rice husk producing differ disintegration, which of comparative studies are indulge. Those evaluation parameters where these different brands of rice husk producing variation in evaluation can reach us to desire rice husk could be uses betterment for enhancement in disintegration process.

Keywords: Dissolution rates, Absorption Enhancement, Rise husk, Pharmaceutical Excipients, Celluloses.