Abstract

QUENCHING METHOD - A NOVEL TECHNIQUE IN THE FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES TAKING QUETIAPIN FUMARATE AS A MODEL DRUG

P. Tripura Sundari* and Hari Anushree

Abstract

The aim of the present study is to formulate and evaluate solid lipid nanoparticles of Quetiapine Fumarate by quenching method. Quenching method is a novel technique in which the drug along with other substances are heated to elevated temperatures and then subjected to rapid cooling with the quenchants like ice cold water or polymeric solutions, which have high heat extracting potential which results in the formation of nanoparticles. Quetiapine Fumarate is an antipsychotic drug used in the treatment of Schizophrenia. Quetiapine Fumarate has poor water solubility and oral bioavailability of 9% due to first pass metabolism. To overcome these problems an attempt was made to prepare Quetiapine Fumarate into Solid lipid nanoparticles which has ability to improve the solubility and enhance the oral bioavailability. In the present study Quetiapine Fumarate loaded SLNs were prepared by a novel technique called Quenching. Ice cold distilled water was used as the quenchant. The Cutina® HR was used as the Lipid, Gelucire 50/13 as lipophilc surfactant and Kholliphor P 188 as Hydrophilic surfactant in the preparation. Among the five prepared formulations Q3 was best with the entrapment efficiency of 86.1%, Drug release of 90.2%, Particle size of 160 nm with Zeta potential of - 35.9 nm. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release.

Keywords: Solid Lipid Nanoparticles, Quetiapine Fumarate, Cutina® HR.