Abstract

SIMULTANEOUS ESTIMATION OF LEVOSULPIRIDE AND ILAPRAZOLE IN CAPSULE DOSAGE FORM BY SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC METHOD AND QABSORBANCE RATIO METHOD

*Devanshi H. Rami and Dr. Sejal K. Patel

Abstract

Two precise, accurate, simple and cost-effective UV spectrophotometric methods have been developed and validated for simultaneous estimation of Levosulpiride and Ilaprazole in Capsule dosage form. Method I is estimation using simultaneous equation method at 231 nm (λmax of Levosulpiride) and 305.6 nm (λmax of Ilaprazole). Method II is Q-absorbance ratio method utilize absorbance of Ilaprazole and Levosulpiride at 219 nm which is the Iso-absorptive point and 305.6 nm the λmax of Ilaprazole. Both methods obeys Beer's law in the concentration range of 2-40 μg /ml for Ilaprazole and Levosulpiride. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The method was successfully applied to the determination of these drugs in pharmaceutical dosage form.

Keywords: Levosulpiride, Ilaprazole, UV spectrophotometry, Simultaneous equation method, Q-absorbance ratio method.