Abstract

EVALUATION OF CHEMOPREVENTIVE ACTIVITY OF SOME SPICES THROUGH CELL VIABILITY ASSAY AGAINST SELECTED CELL LINES

Neeraj Mishra* and K. K. Behal

Abstract

Spices have been traditionally used for prevention and cure of many diseases. Hence, this study was aimed to investigate the effects of aqueous and alcoholic extract of four different spices (asafoetida, ginger, cinnamon and cardamom) extracts on HeLa cell lines, human breast adenocarcinoma cell line (MCF) and HEP-G2 cancer cell lines through cell viability assay. Aqueous and alcohol extract (20 mg/ml) of asafoetida showed better Chemopreventive activity. Cell viability was 14% for aqueous extract whereas 9% for alcohol extract on HeLa cell line; 18% Cell viability for aqueous extract whereas 14% for alcohol extract on MCF-7 cell line; 14% Cell viability for aqueous extract whereas 9% for alcohol extract on HEP-G2 cell line. Therefore, these spices might be used for natural healing of the tumor.

Keywords: Chemopreventive activity, HeLa cell lines, human breast adenocarcinoma cell line (MCF), HEP-G2, Spices.