Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCH OF DICLOFENAC–TIZANIDINE

Juhi Dubey*, Ashwani Mishra, Dr. Vaibhav Dubey and Dr. Narendra Lariya

Abstract

The aim of present research work was to prepare and evaluate transdermal drug delivery of Diclofenac and Tizanidine in combination which necessitates its frequent dosing by oral route. In certain instances skeletal muscle relaxants can also be administered topically. Transdermal drug delivery system of was prepared using combinations of Polyvinyl Pyrrolidone K 30 and Poly vinyl alcohol in different ratios by solvent evaporation technique. Different penetration enhancers were also used like Tween-20, Span-20 and Oleic acid. Plasticizers are a very important excipient in transdermal formulation and in this formulation. Polyethylene glycol 200 is used as a plasticizer. The prepared polymeric Films were characterized for various physiochemical parameters like film thickness, folding endurance, Moisture content, Tensile strength, Moisture vapor transmission, Percentage elongation, Drug content uniformity drug content, In vitro skin permeation, Permeability Coefficient and Flux (J) It was observed in result that Tizanidine -Diclofenac transdermal patch had Polyvinylalcohol, Polyvinylpyrrolidone, plastisizer Polyethylene glycol-200, and solvent system methanol: water formulation code F1, F2 and F3 revealed good in-vitro properties. Hence the transdermal patch would prove to be a promising formulation.

Keywords: Tizanidine, Diclofenac, Plasticizer, transdermal drug delivery, Penetration enhancers.